keybinds settings etc as sup

Before when I only played mid I only had 1 'use-item', all the other items I gathered gave passive perks etc now I'm also getting into the Support role, following builds on mobafire. and support builds have many items with on use items So I was wondering: How exactly do I keybind things? and are there any other settings I need to change? Only thing I've changed about the basic settings is clearcasting my abilities Any tips would be nice thanks
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