"Untargetable"

Hello, I've been playign a lot of Master Yi latley and i was hoping someone could clear up the "Untargetable" thing on his Alpha Strike. So i get that if i Alpha Strike i can be specifically targeted by Warwick's Infinite Duress (His ult) for example but say Karthus has used his ult and i Alpha Strike as the ults timer hits 0 do i still take damage? I ask because i've played against Lux a few times and at times i seem to be able to Alpha Strike over her ult but not other times. Thanks for any help.
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