While arguing that RNG has a too much to do with who wins is becoming old, there are certain combos that you can't win against.
6 Noble pretty much wins every game. If there is a Ninja-Assassin combo in the game you can go f*ck yourself. Glacial-Yordle? Scrape your eyeballs out with a fork.
It's just not fun that your RNG-Luck multiplies with itself in the game. It's ridiculous and NOT A FUN thing. I genreally do things for fun, when I do them voluntary