Imput lag

From time to time, I have a huge imput lag. I can see everything going on without it being laggy or delayed, but when it happens, I cant control my champion anymore. My ping shows not to spike at all (arround 45ms). It changes from game to game. I can play a couple of arams and normals without a problem, and then suddenly one game becomes unplayable. it does not start at the beginning of the game but at a random point in time. has anyone an idea, what might cause this?
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