Game stop responding for few seconds randomly

So, I have this problem. When I played earlier today, everything was working fine, but right now I have this weird lag/game not responding problem. Randomly, game either stop responding completely (even mouse stop responding) or act laggy. Before the moment that I start action (for example using skill) until it will be processed by game, take ages. This happens also with walking. Still, this does not happen on practice mode (went there after restarting PC, Internet and running in-game repair tool), I can move without any problems, nothing wrong happens. Any tips how can I solve this? My FPS is normal (58-60) and my ping between 30-45, stable for the whole game duration. //Edit: fixed mistake in my post. //Edit 2: fixed mistake that I made when writing an edit about mistake that I made when writing a post.
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